- Effects of Haritaki
rejuvenating effect of Haritaki
Terminalia Chebula: Telomere
Scientific experiments and studies on the rejuvenating effect of Haritaki.
In 2004, scientists found that Haritaki extracts inhibited age-related telomere shortening and UVB-induced oxidative damage in vitro.
Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruitPhytotherapy Research PTR 2004 Sep;18(9):737-41. doi: 10.1002/ptr.1529
The ethanol extract from the fruit of Terminalia chebula (Combretaceae) exhibited significant inhibitory activity on oxidative stress and the age-dependent shortening of the telomeric DNA length. In the peroxidation model using t-BuOOH, the T. chebula extract showed a notable cytoprotective effect on the HEK-N/F cells with 60.5 +/- 3.8% at a concentration of 50 microg/ml. In addition, the T. chebula extract exhibited a significant cytoprotective effect against UVB-induced oxidative damage. The life-span of the HEK-N/F cells was elongated by 40% as a result of the continuous administration of 3 microg/ml of the T. chebula extract compared to that of the control. These observations were attributed to the inhibitory effect of the T. chebula extract on the age-dependent shortening of the telomere, length as shown by the Southern blots of the terminal restriction fragments (TRFs) of DNA extracted from subculture passages.[Link to the scientific study]